Our new Very clear+ tissue clearing procedure is the only real method that delipidates samples with no modify in morphology and with small influence on structural integrity.
Megatome is a vibrating microtome made to section a broad selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With large blade vibrating frequency and minimized blade deflection, Megatome allows significant-throughput tissue sectioning with uniform area profile, and minimal tissue harm and information loss.
Antibodies may well acquire months to diffuse by only some millimeters of tissue, which has a steep labeling gradient from area to Main.
Megatome is suitable for precision: the blade vibrates at an increased frequency and bigger amplitude assortment than other microtomes, and incorporates a special deflection Handle mechanism.
SE takes advantage of a rotational electric powered subject to disperse hugely electromobile molecules (for example antibodies or surfactant micelles) during a porous sample with out damaging electrically billed buildings in the tissue. This permits 2-four working day clearing of intact organs,
Our preformulated EasyIndex Resolution raises and homogenize the refractive index of delipidated tissue samples, rendering them completely transparent. This allows gentle penetration to the sample and guarantees the acquisition of superior-resolution, in-concentration impression information.
Megatome is usually a novel microtome that enables for high-precision sectioning megatomi.com of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with negligible tissue hurt and information decline.
It’s time to up grade your microtome to Megatome. With correct superior-frequency slicing for an unmatched array of sample dimensions and types – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for numerous apps.
The SmartSPIM light-weight sheet microscope offers unparalleled resolution and acquisition speed in the course of intact tissue volumes, although its modular structure lets you upgrade and personalize individual elements.
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Defend avoids the variability of hydrogel embedding and the data decline from PFA preservation, defending specimens for many rounds of processing.
Leverage the Obvious+ tissue clearing system, along with eFLASH and patented stochastic electrotransport technologies, to swiftly crystal clear and label full organs. Key highlights and functions incorporate:
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